Mon, 15 Feb 2010 21:02:31 +0000

February 7th, 2010

By Steve Dorsey

We’re deep into Day Two of the 31st Best of News Design™ Competition. The original judging teams have worked through their primary assignments and have now been recombined to create a new graphics team. The new magazine categories are getting their first close look on the judging tables (also known as the killing fields) and the Winner-meter™ has been busy keeping up with the now steady stream of nearly 450 awards of excellence, 26 silver medals and now — ta-da — our third gold medal (and we suspect the first-ever for a Chinese newspaper).

Congratulations to the Chinese Business Morning View, and especially to illustrator Jing Ma.

9. Special coverage / single subject

GOLD
Chinese Business Morning View (Shenyang, China)

For the 60th anniversary of the establishment of the People’s Republic of China, the Chinese Business Morning View of Shenyang, China, undertook an epic concept: they published an interconnecting illustrated panel every day celebrating some aspect of their history and culture — for 2 entire months. That’s 60 installments. The panels are reminiscent of traditional Chinese paintings in their style and in their very shape. They tell a story in a visual timeline form, descending from the top to the bottom of each panel. The panels themselves connect and continue horizontally day-to-day, forming a single continuous landscape. And they were drawn by a single artist — illustrator Jing Ma (working with design director Fang Fang).

The judges thought the work took an interesting leap of faith. To do this every day for 2 months and then trust that your readers are going to track it and assemble it in some cases, is epic. It’s done by one illustrator and it’s gorgeous. And there’s rich meaning behind it. They’re showcasing their people and their culture in such a compelling and unique way.

Your natural instinct would be to do the timeline left to right but they’ve woven it into each panel vertically. They’ve done so much work and you get so much more out of it as a result. It’s as much like a puzzle as a mural, more like a tapestry. It connects in two different dimensions

The panels are reminiscent of Chinese scrolls. The judges said they’ve seen the these additive panels before but never like this — over 60 days!

The judges thought it was an effective way to get the readers involved in the publications too: you can start at any point in the series and it still makes sense. Each individual piece is a complete unit, but they fit within a larger context too. You can’t do this kind of thing with anything else but a daily newspaper, the judges said. If we were teachers we’d put these panels up in our classroom — not just to teach history, but it also encourages people to read. It’s a rich alternative form of telling a story.

This post was tagged: Illustration

CONCLUSION: The results of this clinical microscopy study are summarized as follows and shown in figure 2:
1.  Pacemaker Technologye (PTSM)  treatments result  in an  overall  improvement in terms of normalized RBCs separation.
2. On the average, RBCs separation appears to linearly improve with increased number of  treatments.
3.  Pacemaker Technologye  treatments appear to have a negative correlation with the number of  fungal forms, poikilocytosis, thrombocyte aggregation and bacteria present in the blood prior to the PTSM treatments, demonstrating a significant reduction of all of the above mentioned variables.
4.  The enhanced erythrocyte separation as well as the reduction of fungal forms, poikilocytosis, thrombocyte aggregation and bacteria persisted during the intervals between treatments.  A longitudinal study is necessary to investigate the total length of time during which such normalization effects continue to be present.  So far, two subjects that have been followed up over a period of three months have sustained the Pacemaker Technologye’s positive effects on RBCs separation.

(figure 2)

This technology that was initially based on research associated with the Pacemaker and gained its popularity in the field of body building and cosmetic procedures  is now coming full circle by offering benefits that can be potentially used in Medicine to reduce the incidence or progression of cardiac disorders resulting from erythrocyte aggregation.   PTSM treatments effortlessly exercise the body without lactic acid production while enhancing RBCs separation.  This process of exercising without actually exercising could solve the dilemma caused by intolerance to Statins which is associated with intolerance to exercise.

INTOLERANCE TO STATINS:
It is well recognized that Statins, medically used to down regulate the blood coagulation cascade, affect muscular tissue adversely.  Treatment with Statins is associated with clinically important myositis, rhabdomyolysis, mild elevation of serum creatine kinase (CK) levels, myalgias, muscle weakness, and muscle cramps. In Statin patients muscular problems occur more frequently during and after exercise (Franc et al, 2003 ; Searchrist et al, 2005). Sinzinger and O’Grady (2004) found that 78% of professional athletes with familial hypercholesterolemia could not tolerate therapy with any Statin due to muscle pain and cramps.  There is a growing evidence that Statins promote apoptosis in different cell types including vascular smooth muscle cells, and endothelial cells (Kaneta et al., 2003; Shellman et al, 2005; Wibaut-Berlaimont et al, 2005).  Pacemaker Technologye (PTSM) treatments result in RBCs separation.  Such normalization of blood flow can possibly reduce the risk of heart disease reducing the need for Statins.  Additionally, Pacemaker Technology effortlessly exercises  the muscles without lactic acid formation, thus reducing intolerance to Statins.

MITOCHONDRIA AND AGING:
Abnormal mitochondrial function and  compromised energy production are an increasingly recognized cause of neuromuscular disease and aging. Evidence of impaired rephosphorylation of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) during recovery from exercise was found in almost half the patients (Arnold 1984).    ADP is transformed into ATP via the proton motive force (driven by the electron transport chain) that spins the ATPase module clockwise. Without the proton motive forcer the ATPase module spins anti-clockwise breaking energy down (dephosphorylation of ATP into ADP and a Phoshate.)  The miniscule ultra low microcurrent of the Ion Mangum offers the system an influx of electrons which in conjunction of the enhanced oxygen transport, the result of erythrocyte separation, can facilitate and increase ATP production.  Note that the ATPase module is a key time reversal mechanism, spinning clockwise to produce energy and anti-clockwise, or backwards to break it down.    This can perhaps explain the significant anti-aging effects consistently observed after Pacemaker Technologye treatments.

CALCIUM HOMEOSTASIS & AGING:
Chua et al, (2005) evaluated eleven patients with increased creatine kinase (CK) levels and myalgias after Statin treatment, using in vitro contracture tests (IVCTs), histology, and 31P magnetic resonance spectroscopy (31P-MRS).  IVCT results were abnormal in 7 out of 9 patients, indicating an impaired calcium homeostasis. Calcium homeostasis refers to the regulation of the concentration of calcium ions in the extracellular fluid [Ca++]ECF. This parameter is tightly controlled because the calcium ions have a stabilizing effect on voltage-gated ion channels which are responsible for generation of electrical signals in cell membranes. For instance, when [Ca++]ECF is too low (hypocalcemia), voltage-gated ion channels start opening spontaneously, causing nerve and muscle cells to become hyperactive. Conversely, when [Ca++]ECF is too high (hypercalcemia), voltage-gated ion channels don’t open as easily, and there is depressed nervous system function. Another problem of hypercalcemia is that calcium can combine with phosphate ions, forming deposits of calcium phosphate (stones) in blood vessels and the kidneys. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration and aging (Lally et al, 2005). Peterson et al, (2006)  reported that Alzheimer’s donors have higher levels of bound calcium but lower concentrations of free intracellular calcium when compared to cells from young and normal aged donors.  Squil et. al’s research (2008) in the National Institute of Anti-aging focuses on the molecular mechanisms that result in the age-dependent loss of calcium regulation in neurons, which correlates with an increased sensitivity to stress and age-related declines in cognitive function. They are presently working in trying to identify a linkage between oxidative stress and decreased calcium regulation observed during aging.    The intimate connection between ion channels, the  electrical heart of the cell, and calcium homeostasis places Pacemaker Technologye’s key to lock bio-resonant waveform  center  stage.   A signal in sync with the nervous system  may be absorbed by the system to regulate and stabilize ion channels and hence  normalize overall nervous system functioning, offering an ion based time reversal mechanism.

OXIDATIVE STRESS AND AGING:
Oxidative stress has been postulated as one of the primary causes of aging from a number of investigators (Landis et al, 2004).  Sinclair et al, (2007) in Harvard University has identified identical biological substrates in oxidative stress and aging.  Oxidative stress can be effectively combatted by an electron influx donating the missing electrons to free radicals.  Free radicals that receive their missing electron are transformed back into their original form of stable molecules — a basic yet, very powerful time reversal mechanism.
The consensus on the electrical properties of DNA is that DNA utilizes electrons to deflect oxidative damage from itself, safeguarding against aging, disease and impaired protein formation.  Impaired protein formation leads to diminished cellular intelligence, as proteins are the brain of the cell. Electrons, the key element against oxidative damage, are the very essence of Pacemaker Technologye’s ultra microcurrent signal.

IONIC FACTOR SEEN AS A BIOLOGICAL HUB:  Several of the common denominators of intolerance to Statins and aging appear to be related to insufficient biological ionic biological activity represented by: a) impaired calcium homeostasis affecting ion channels, b) mitochondrial impairment leading to energy shortage, and c) oxidative stress, as a result of free radicals which are stable molecules missing one of their electrons.  PTSM bio-resonant signal  can spread into the CNS to enhance ATP production in the mitochondria.  It can donate electrons to the electron seeking free radicals hence turning them into stable molecules to reduce oxidative damage.  Reduced oxidative damage will allow for healthier DNA and proteins. PTSM key to lock bio-resonant waveform may be absorbed by the system and utilized in ion channels regulation which may play a central role in reversing neuro-degeneration and aging.  From this point of view ionic activity can be seen as a biological hub interconnecting a number of biological activities that are crucial in anti-aging as well as the maintenance of an optimal health status

DIABETES MELLITUS II
Individual phenotypic differences result in a variation of T4 to Free T3 conversion. Free T3 stimulates lipolysis. This leads to polymorphic and individualized lipid deposition patterns. Hyperthyroidism is associated with weight loss via an increase in metabolic rate and lipolysis. A  literature review  by Guillermo et al, (2003) has shown that the risk of thyroid dysfunction in Diabetic patients is two to threefold higher than in the general population. Although the benefits of intensified insulin treatment in insulin dependent Diabetes Mellitus are well recognized, a meta-analysis of 14 randomized controlled trials revealed the risk of severe Hypoglycemia, Ketoacidosis and mortality from acute metabolic causes with intensified insulin treatment. These 14 trails contributed 16 comparisons with 1028 patients allocated to intensified and 1039 allocated to conventional treatment. A total of 846 patients suffered at least one episode of severe hypoglycaemia, 175 patients experienced ketoacidosis and 26 patients died. We are investigating an alternative treatment for Diabetes with no side effects. This involves the enhancement of endogenous production of Free T3 and IGF-1 via the Pacemaker Technologye signal.
1. PTSM Initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity. 2. Once the process is initiated, the motor neurons signal the brain  via  the spinal  cord. This  is  a  physiologically reversed process, where the strenuous exercise signal does not originate in the brain traveling down the spinal cord. Instead, the process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission. 3. This CNS emission causes the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy. The enhanced production of Free T3 and GF/IGF-I will temporarily cause hyperglycemia which will resolve once the glucose has been utilized for metabolic purposes, energy increase
and muscular hypertrophy.

SUMMARY: Pacemaker Technology treatments appear beneficial in A. Muscle Building; B. Lipolysis; C. Anti-Aging; D. Erythrocyte Separation; E. Possibly Reducing the risk of Heart Disease; F. Reducing Oxidative Damage; F. Possibly Reducing the need for Statins; G. Possibly Reducing intolerance to Statins; H. Increasing ATP; I. Possibly Re-establishing Calcium Homeostasis.  J. Enhancing Secretion and Transport of Thyroid and Growth Hormones.

IONIC TECHNOLOGY AND DYNAMIC AGE REVERSAL:
According to the microscopic laws of physics, for every allowed process there exists a time-reversed process, a principle that applies to molecular biological events.  For example, Shanklin et al (2006) found that a single substitution in the amino acid sequence of an enzyme seemed to turn the clock 2.5 billion years back.
Endogenous ionic activity appears to be crucial in a number of key bio-molecular processes as well as life sustaining and reparative mechanisms:
1. Amino acids form proteins, being attracted to each other by virtue of their electrical charges.
2. Electrons turn the clock back by transforming free radicals into the stable molecules they were prior to oxidative damage.
3. Driven by the Proton Motive Force, ATPase rotates clockwise to produce ATP or anti-clockwise to break ATP down to ADP and a Phosphate.
4. DNA uses electrons to deflect oxidative damage away from its important sections.
5. The body is empowered by endogenous electrical fields to heal itself.
6. Ion Channels are involved in cell division and differentiation, initiation of immune responses and bio-electrochemical communication.
In conclusion, several life sustaining and time reversal processes appear to be electrical.

The single minded focus of this research group is to continue fine tuning ‘device — body’ communications on the basis of knowledge accumulated by the Pacemaker technology specializing in the unique interaction between electronic keys fitting biological lock mechanisms.

References:
Peterson C, Ratan R, Shelanski M, Goldman J. Changes in Calcium Homeostasis during Aging and Alzheimer’s Disease.  Annals of the New York Academy of Sciences. 2009; 568: 262 - 270
Lally G, Faull RLM, Waldvogel HJ, Ferrar S, Emson PC. Calcium homeostasis in ageing: studies on the calcium binding protein calbindin D28K. J of Neural Transmission. 1997; 104: 1107-1112
Catterall W. Structure and Function of Voltage-Gated Ion Channels. Annu. Rev. Biochem. 1995. 64: 493-531
Zhang JD, Han J.  A modular network model of aging.  Molecular Systems Biology. 2007: 3:147
Zhao M, Song B, Pu1 J, Wada T, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-g and PTEN. Nature 2006; 44: 2|27-2138
Uchikoga N, Takahashi SY, Ke R, et al. Design and self-assembly of two dimensional DNA crystal. Nature. 1998 394-539
Pidder JD,  Heinz DO. Healthy ageing: a question of stress, damage and repair. Meeting on mechanisms of biological ageing.  EMBO Reports. 2002;  3: 12: 1127–1132